Novel 1, 2, 3-triazolic compounds derived from cytosine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies
The development of novel antimicrobial drugs is crucial due to the increasing problem of antibiotic resistance.A new series of 1,4-disubstituted-1,2,3-triazole derivatives containing a cytosine moiety (3a, 3b, 3c and 3d) were synthesized 30x24x24 wall cabinet using 1,3-dipolar cycloaddition in a mixture of ethanol and water under Cu(I)-catalyzed wi